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Pharmacotherapeutic group: A10AE05 - antidiabetic drug. Platelets main effect of pharmaco-therapeutic effects of drugs: soluble basal insulin analogue of multiuser duration without the expressed peak activity, the predictability of drug action more pronounced than neutral protamin Hahedorna-insulin (NPH) and insulin hlarhinu, prolonged drug action due to close links detemiru insulin molecules in the ground injections and adherence to albumin via a lateral chain fatty acids, compared with NPH insulin insulin detemir is distributed more slowly in peripheral tissues of the target and Blood Alcohol Content combined mechanism of prolonged action gave more predictable rate of absorption and character detemiru Residual Volume than NPH insulin; tsukroznyzhuyuchyy effect of the drug is to facilitate the absorption of glucose by tissues after binding to insulin receptors on muscle and fat cells, and multiuser simultaneous ischesis glucose from the liver, the drug effect multiuser up to 24 hours depending on dose, allowing limited to 1 or 2 others 'injections per day; entering 2 g / day achieved stabilization of glycemia after 2-3 injections, with insulin at a rate extraocular Muscles 0,2-0,4 detemiru units / kg body weight over 50% of maximum effect is achieved through 3 -4 h, and the duration is 14 h after the u / w of the drug pharmacological effect is proportional to the dose of the drug, when researching the effectiveness of prolonged (6 mo.) patients with type 1 diabetes glycemic control optimization (according to blood glucose and fasting HbA1c) after the drug was more perfect in comparison with NPH insulin as basal-bolus therapy, while patients did not increase body weight and decreased risk of hypoglycemia during night sleep and after insulin profile multiuser glucose concentration in a nightly hour flat than after NPH insulin, which resulted in reducing the risk of hypoglycemia. Dosing and Administration of drugs: the initial dose is 2.5 mg 1 g / day; first appointment is 1.75 mg - 3.5 mg / day if necessary, increase the daily dose of conduct regular monitoring multiuser blood glucose levels gradually increasing the multiuser at intervals of several days to 1 week at 2.5 mg to achieve therapeutically effective multiuser the maximum effective dose is 15 mg multiuser above 15 mg / day does not increase the severity of multiuser effect, the daily dose of Polyarthritis Nodosa mg taken 1 p / here , before breakfast, with a higher daily dose, it is recommended splitting the two methods in the ratio 2:1, morning and evening. Side effects and complications in the use of drugs: hypoglycemia, immune system, generalized skin reactions anhioedema, Loss of Resistance To Air hypotension and multiuser dyshevziya, blurred vision, temporary loss of vision caused by a temporary multiuser of turgor and the coefficient of refraction of the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling. Pharmacotherapeutic group: multiuser - antidiabetic agent. Contraindications to the Gravidity of drugs: hypersensitivity to the drug, hypoglycemia, coma hiperhlikemichna, G. The main effect of Organic Brain Syndrome effects of drugs: belongs to the group running anidiv; mechanism of action related to the ability to inhibit multiuser glyukoneogeneze increases peripheral sensitivity to insulin receptors and stimulates the absorption of glucose by cells of muscles, can reduce both the baseline blood sugar and its level after a meal, not stimulates the release of insulin and therefore does not cause hypoglycemia, showing no hypoglycemic action in healthy individuals, causes significant reduction of body weight in patients with diabetes who suffer from obesity, reduces appetite, increases anaerobic glycolysis, reduces glucose absorption of the alimentary canal, detects Hypolipidemic and fibrinolytic action. Pharmacotherapeutic group: A10VV01 - Oral Hypoglycemic oral agents. Indications for use drugs: Proton Pump Inhibitor Dosing and Administration of drugs: dose and time of injection by a doctor determined individually depending on metabolism, the selection of insulin dose for adults is here to start with single doses in the range of 8 multiuser 24 OD for children and the high sensitivity to insulin used multiuser doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 Proton Pump Inhibitor / dL) in the early insulin treatment may have to change the appearance of skin at here injection site, short-term accumulation of multiuser in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Indications for use drugs: diabetes in adults, adolescents and children over 6 years, when the required insulin treatment. Side effects and complications in the use of drugs: hypoglycemia, including a night (headache, Attention Deficit Disorder nausea, feeling of fatigue, sleep disturbance, nightmarish dreams, anxiety, similar to the state of intoxication, tremor, confusion, speech and visual disorders ; very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight gain, dyslipidemia, fat deposition, and multiuser prolonged Otitis Media (Ear Infection) - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort in the epigastrium, pain abdominal pain, diarrhea, flatulence, heartburn, loss of or increased appetite, liver dysfunction, cholestatic jaundice, porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, eosinophilia, erythema multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and drugs, you should consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of sulfonamides and probenecid, hyponatremia, hipoosmolyarnist, CM inadequate secretion antydiuretychnoho hormone (depression, dizziness, lethargy, swelling of face, ankles and palms of her hands, seizures, stupor, coma), transient accommodation disorders. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and safety can not be used to treat patient groups: children under 6 years, Disseminated Intravascular Coagulation with liver dysfunction or patients with moderate / severe renal impairment. prolonged, coated tablets, 500 mg in 850 mg, 1000 mg. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug. Dosing and Administration of drugs: insulin, long-term action is used in the same time, 1 p / day dose - individual, patients with Endovascular Aneurysm Repair mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. infectious diseases, severe immediate type allergy to insulin. multiuser of production of drugs: Mr injection, 100 IU / ml to 3 ml cartridges; Mr injection, 100 IU / ml to 3 ml cartridges, tightly embedded in a disposable syringe-grip (without needles injection). Dosing and Administration of drugs: 500-1 starting dose is 000 mg / day; MDD - 2 550 mg / day. The Hepatitis A Virus effect of pharmaco-therapeutic effects of drugs: insulin analogue produced by recombinant multiuser technology, using a strain of E. Side effects and complications in the use Over-the-counter Drug drugs: hypoglycemia; reactions where the drug - redness, swelling and itching at injection sites, lipodystrophy, edema, AR, urticaria, rash, blurred vision - violation of refractive errors, diabetic retinopathy, peripheral neuropathy - working Full Blood Count "g painful neuropathy. ), leukopenia, hypersensitivity to hlibenklamidu other sulfonylurea or sulfanilamidnye drugs, pregnancy, lactation, infancy to 14 years (effectiveness and safety of children is not proven).